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The role of hypoxia-inducible factor 1-alpha (HIF-1a) in this context is particularly noteworthy

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doi: 10.1001/jamaoncol.2018.3676 140 OhgakiHKleihuesP

This reduces the permeability of the BBB, preventing harmful substances from entering the brain, improving microvascular stability, and alleviating the pathological changes of epilepsy and other brain diseases

[4] People with conditions that irritate mucosal lining in the stomach and intestines, such as Crohns or celiac disease, [7] chronic alcoholism, or inflammatory bowel disease