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Because their mechanisms do not overlap, stacking them creates a two-pronged approach: Retatrutide reduces caloric intake and boosts metabolic rate from the top down, while AOD-9604 attacks stored fat at the cellular level from the bottom up

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Funding This work was supported by the National Natural Science Foundation of China (82372405, 81871752), the Key Research and Development Program of Hubei Province (2022BCA052), the Key Research and Development Program of Wuhan City (2024020702030105), the Fundamental Research Funds for the Central Universities (2042023kf0199), and the Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University (ZNJC202014)