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10.1007/s11899-015-0253-6 Curr Hematol Malig Rep

Jul 2021;9(7):3556-3562

In support of a functional association, heterologous GSTP1 expression in Saccharomyces cerevisiae (Black et al, 1990) or of various GSTP1 alleles in Escherichia Coli influenced sensitivity to platinum and additional chemotherapy drugs (Ishimoto and Ali-Osman, 2002)

Buendia L, Girardin A, Wang T, Cottret L, Lefebvre B (2018) LysM receptor-like kinase and LysM receptor-like protein families: An update on phylogeny and functional characterization

Based on of these preclinical studies, in 2018, started an open label trial to test the effects of oral EGCG treatment on lung tissues and serum samples obtained from 20 patients with IPF and it is titled Fibroblast Specific Inhibition of LOXL2 and TGFbeta1 Signaling in Patients With Pulmonary Fibrosis. Half of the patients were given orally EGCG before they underwent biopsy, and the other half did not receive the treatment