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Systematic Review Orthopaedic Sports Medicine (2025) The 2025 systematic review by Vasireddi, Hahamyan et al

Possible explanations include: Placebo effect : Expecting increased energy may influence perceived alertness Correction of deficiency : People with B12 deficiency often experience fatigue and disrupted sleep patterns

Studies suggest that KPVs anti-inflammatory mechanism is independent of melanocortin receptors and involves direct entry into cells, distinguishing it from full-length -MSH signaling