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Additionally, longitudinal studies examining the immediate, intermediate and long-term effects of elevated Mn exposure on children and adults are needed to identify age- and sex-specific susceptibilities, and potential biological, psychological and cognitive biomarkers

From a clinical perspective, exposure to anabolicandrogenic steroids should be considered in the differential diagnosis of a wide range of conditions affecting physically active young adults, including cardiomyopathy, arrhythmias, infertility, hepatic dysfunction, mood instability, and unexplained endocrine abnormalities

58 Complement components such as C3, C4c, C5, and C7 are upregulated in glomeruli, 63,64,65,66,67 activating both the classical and alternative complement pathways and generating anaphylatoxins (C3a and C5a)