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doi: 10.1016/S1470-2045(21)00630-6 330 PostowMACallahanMKBarkerCAYamadaYYuanJKitanoSet al

The phosphoinositide-gated lysosomal Ca (2+) channel, TRPML1, is required for phagosome maturation

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The complex, multi-factorial pathogenesis of SAH, with intertwined pathways, strongly suggests that single-agent therapies may be insufficient to achieve sustained clinical benefit [14,31]