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However, despite the discovery of anti-vimentin autoantibodies, other studies refuted that they could have a profound impact on the overall pathogenesis of the disease (99)

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Combined with other internal sources of oxidative stress, like inflammation and psychoemotional stress, and external sources, like ultraviolet radiation, we get a buildup of oxidative stress over decades that may cause our melanocytes, the pigment-producing cells, to age and die off

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Also, some studies have exposed differences with MDD regarding immune cell populations