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When a patient is truly low in B12 common in older adults, in people with GI conditions like Crohn's or celiac, and in those on vegetarian or vegan diets the symptoms are textbook fatigue, weakness, and cognitive fog, and replacing the missing nutrient can resolve them

Similarly, in another study, 34% of patients with vitiligo had a history of thyroid disease (Yaghoobi et al., 2011)

Aging 9, 2489.CrossRefGoogle ScholarPubMed Cuanalo-Contreras, K, Mukherjee, A & Soto, C (2013) Role of protein misfolding and proteostasis deficiency in protein misfolding diseases and aging

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In these reactions, -KG is oxidized to succinate, and increasing levels of succinate can suppress the progression of -KG-dependent histone or DNA demethylase reactions 98