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Reconstituted solutions should be protected from reducing agents (such as DTT or beta-mercaptoethanol), which can cleave the disulfide bond and disrupt the active conformation

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This background pain may appear in up to 24%49% of patients, and may be described as burning, stinging, or pulsatile.22,23 The most recent data do not fully support the theory that continuous pain is the result of longstanding paroxysmal TN.23 While the underlying pathophysiological mechanism is not fully understood, it is believed to involve central sensitisation and damage to C fibres of the nerve root

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