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Beyond its established roles in autoimmune disorders, neurodegeneration, and cancer, ferroptosis exhibits distinct organ-specific features in the kidney, where its activation is tightly linked to the disruption of renal iron homeostasis, lipid metabolism, and antioxidant defense systems (278, 279)

Eur J Clin Pharmacol 50:45761 Herzenberg LA, De Rosa SC, Dubs JG, Roederer M, Anderson MT, Ela SW, Deresinski SC, Herzenberg LA (1997) Glutathione deficiency is associated with impaired survival in HIV disease

Proc Natl Acad Sci USA 101:1385013855 Cherukuri S, Potla R, Sarkar J, Nurko S, Harris ZL, Fox PL (2005) Unexpected role of ceruloplasmin in intestinal iron absorption