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Thats when oxidative stress builds up and starts causing damage at a deeper level

Mitochondrial control of apoptosis through modulation of cardiolipin oxidation in hepatocellular carcinoma: A novel link between oxidative stress and cancer

Furthermore, in some cell models, a small proportion of DTCs can resume normal growth and form cell populations even in the presence of drugs, indicating that in a few cases, DTCs can also mutate and cause drug resistance (12)

[DOI] [PubMed] [Google Scholar] 5.Bergmeister K.D., Groe-Hartlage L., Daeschler S.C., Rhodius P., Bcker A., Beyersdorff M., Kern A.O., Kneser U., Harhaus L