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Dose Separation: Is Timing Important

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Many studies that have shown a relation between PM 2.5 exposure and risk of cardiac morbidity (31), altered respiratory responses to physical activity (32) and all cause mortality (33, 34), and the mechanism by which these associations occur, appear to be related to an inflammatory response with accompanying functional effects

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Increased expression of insulin/insulin-like growth factor-1 hybrid receptors in skeletal muscle of noninsulin-dependent diabetes mellitus subjects