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Moreover, elevated levels of leptin, a prevalent occurrence in individuals with obesity, have been shown to stimulate the secretion of vascular endothelial growth factor (VEGF) by airway ASM cells (293), suggesting that leptin may indirectly contribute to the obesity-induced bronchial vascular remodeling processes in individuals with asthma and obesity

The GSH/GSSG content and ATP levels of 0.51 10 5 cells/well were measured by a luminescent-based assay (Promega V6612 for GSH/GSSG and Promega G7571 or Sigma MAK135 for ATP) following the manufacturers protocol

Diabetes affects the activity of many metabolic pathways (AGEs, PKC, polyol pathway, PP), and one consequence of activating these metabolic pathways is the generation of ROS (Kowluru, 2023)

None of the other chromosomes bears all the three genes

16 , e8982 (2020)