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Valko M, Jomova K, Rhodes CJ (2016) Redox- and non-redox-metal-induced formation of free radicals and their role in human disease

Published: June 7, 2018 Copyright: 2018 Lutchmansingh et al

Sustained mPTP opening collapses the mitochondrial membrane potential (m), uncouples oxidative phosphorylation, and causes osmotic swelling, outer membrane rupture, and the release of pro-apoptotic factors such as cytochrome c, thereby initiating caspase-dependent apoptosis