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In contrast, deletion or inhibition of GPX4 causes rapid H 2 O 2 accumulation and RIPK3-mediated necrosome activation 72,73

Although few studies have examined the potential side effects of natural products, some experimental data indicate that they may exhibit dose-dependent cytotoxicity

The striatum and substantia nigra (SNc)-ventral tegmental area (VTA) regions were used for the stereological analysis, with specific cell markers such as tyrosine hydroxylase (TH), neuropeptide Y (NPY), and somatostatin (SST) quantified in these regions

All aspects of the immune response pathophysiology should be considered in the experimental design, which help to clarify the potential role of the liver immune system in aggravating tissue damage or promoting regeneration

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