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DKK-1 induces LRP5/6 endocytosis in cardiomyocytes, causing GPCR signalling disorder and promoting ischaemia-induced DNA damage in cardiomyocytes

doi: 10.1073/pnas.1203519109, 53 VoroninD.TricocheN.PegueroR.KaminskaA

This is a protein that is low expressed in normal tissues and significantly increased in fibrotic tissues and is an ideal target to mark and detect myofibroblast activation [282, 283]