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The correlation between response to oral cyclosporin therapy and systemic inflammation, metabolic abnormality in patients with psoriasis

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While systemic dihexa half life remains one to two hours, CNS concentrations may persist for four to six hours because the peptide is delivered to the target site without requiring blood-brain barrier penetration

The third mechanism is systemic anti-inflammatory signaling, which reduces the inflammatory load that would otherwise slow the structural remodeling process in tendons, ligaments, and muscle