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Etoposide (140mg/m2 iv.once weekly) + dexamethasone (10mg/m2/d p.o.) was started immediately

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DOI:10.1038/nn1609 [ Links ] 6

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Unlike exogenous GH administration which bypasses the pituitary entirely and suppresses endogenous GH production via negative feedback on the hypothalamic-pituitary axis MK-677 recruits the endogenous pituitary machinery, theoretically preserving somatostatin-mediated feedback regulation