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XX wieku w badaniach zespou Predraga Sikia i wsppracownikw z Uniwersytetu w Zagrzebiu (Siki et al., Journal of Physiology , 1993)

Moreover, our structures reveal a distinct binding mode of inverse agonists with receptors, define cavities for ligand recognition, and decipher the action mechanism of inverse agonists and agonists for ghrelin receptors