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NaBPC157 is useful in an anti-tumor therapy

For the change in LVEF, the Z-curve crossed both the traditional and superiority boundaries, indicating sufficient evidence [Supplementary Figure 9]

N Engl J Med 365:327336 de Zeeuw D, Akizawa T, Audhya P, Bakris GL, Chin M, Christ-Schmidt H, Goldsberry A, Houser M, Krauth M, Lambers Heerspink HJ, McMurray JJ, Meyer CJ, Parving HH, Remuzzi G, Toto RD, Vaziri ND, Wanner C, Wittes J, Wrolstad D, Chertow GM (2013) Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease

While confounding is ideally addressed during the design phase, it is challenging in mycotoxin research due to the ethical and practical difficulties of conducting intervention studies that involve randomization, pairing, or matching