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In mice, knockout of ChREBP has been shown to reduce hepatic fatty acid synthesis by 65% compared to wild-type controls, but also to promote insulin resistance, delayed glucose clearance, and severe intolerance to simple carbohydrates, such as sucrose and fructose (resulting in death in the majority of animals) due to an inability to shunt fructose into glycolytic pathways [48]

The activity of key enzymes like CBS and CGL is regulated by feedback mechanisms and can be influenced by the cellular levels of substrates and products

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TNF-/IFN- synergy amplifies senescence-associated inflammation and SARS-CoV-2 receptor expression via hyperactivated JAK/STAT1