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As such, it appears that COVID-19 (and other viral infectious diseases) is accompanied by three different inflammatory phases: (a) beneficial protective inflammation, which combats the infection and may mount a restorative repair, (b) hyperinflammation, which may lead to a cytokine storm and critical disease or even death, and (c) non-resolving inflammation resulting in a protracted mild inflammatory state [105] as observed in Long COVID

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TPP acts as an essential cofactor for three key metabolic enzyme complexes: pyruvate dehydrogenase, which converts pyruvate to acetyl-CoA for entry into the citric acid cycle