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A small pediatric study reported normalization of alanine transaminase (ALT) by 5.5 months in children with mild AIH (elevated liver enzymes with no portal hypertension) using azathioprine alone for induction [86]

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Of note, projection of the first two PCs (PC1 and PC2), which covered maximum variations, showed a considerable compact cluster distribution (centered between 50 to + 50 plane) for the residual motion in the mh-Tyr structure docked with all the ligands during 100 ns simulation, except in mh-Tyr-EC complex (centered between 100 to + 100 plane), by comparison to apo-mh-Tyr (centered between 50 to + 50 plane) (Fig