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Diabetes Assoc., San Antonio, Texas, USA

One of the earliest and most important examples is insulin, which dramatically improved outcomes for people with diabetes after its discovery in 1921

Pain 34 , 450467 (2018)

Once TMAO formation/concentration is elevated, it may increase the risks of atherosclerosis for healthy individuals ( TMAO and HF HF is defined as a group of syndromes caused by structural or functional damage that results in impaired ventricular filling or cardiac output, and which involves multi-organ and systemic neurohumoral dysfunction (89)