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Toll-like receptors (TLRs), a well-known class of PRRs, might be involved in the cytokine storm brought on by SARS-CoV-2 [67]

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The binding of Dectin-1 with - glucans can start and control the innate immune response (142, 162), such as phagocytosis, inflammatory cytokines production, ROS production, and pro-inflammatory factors production, leading to the elimination of infectious agents (158, 164, 165)

Individuals with Raynauds disease experience exaggerated vascular responses to cold that can cause tissue damage and should avoid cold therapy

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