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Depending on the nature of this final cleavage, the procedure can be modified to give a C-terminal acyl thiocyanate peptide product which automatically rearranges to a thiohydantoin incorporating the penultimate C-terminal unit

This process is mediated by glutaredoxins (GLRXs, also known as GRXs), which catalyze both glutathionylation and deglutathionylation, as well as by sulfiredoxins (SRXs) 9,10

Bibcode:2000Sci...289.1567M

Furthermore, the previous research about the correlation between the gut microbiota and the occurrence and development of IBS has been observed and the gut-brain axis plays a vital role, which was consistent with the hypothesis of PD originates in the gut (Braak et al., 2006

4g and Supplementary Table 4)