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Rodents infused with angiotensin II had greater gut permeability as assessed by FITC-Dextran [92, 48] and decreased intestinal gene expression of tight junction proteins including ZO-1, particularly on a low fibre diet [48, 96], which was accompanied by increased intestinal expression of the inflammatory cytokines TNF- and IL-6 [96]

Physiological activation during normal healing operates differently than sustained pathological activation in cancer

GSAO specifically targets proliferative endothelial cells, which consequently starves the tumor of the nutrients required to support its expanding growth (Don et al., 2003

In: Pantopoulos K, Schipper HM, editors

There is no known enzyme specifically to deal with OH, since the OH non-selectively reacts instantaneously with the nearest nucleophilic biomolecules