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Large-scale, double-blind, placebo-controlled human randomized trials are lacking

Might be somewhat helpful in attracting water to the upper layer of the skin Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles

This direct contact may enhance local tissue effects beyond what systemic administration achieves

Depression models: P21 shows antidepressant-like effects in animal models of depression, potentially through neurogenesis enhancement and GSK-3 inhibition

Melatonin has recently received increased attention for its enormous potential in a wide range of different pathologies