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found a new biological element that can directly react with phenolic antioxidants (such as t-butylhydroquinone) in mice, and named it as antioxidant response element, also known as electrophile response element (EpRE) ( Keap1-Nrf2 Pathway and Autophagy The selective autophagy substrate p62 contains an ETGE-like motif, STGE, which could be phosphorylated by mTOR complex 1 to bind to Keap1 with higher affinity (Taguchi et al., 2012)

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Both zinc finger transcription factors are capable of inducing resistance, independently of the ABC transporter (106)