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The increases in LTB4 concentration and ALOX5 expression in adipose tissue are required for the exacerbation of insulin resistance observed in PDK1-knockout mice compared with wild-type controls

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Front Microbiol 12:676436

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393 Other novel targets P2Y14R, a member of the purinergic receptor family, has been shown to promote the transcription of RIPK1 through the cAMP/PKA/CREB signaling axis, thereby driving necrotic apoptosis of intestinal epithelial cells and exacerbating intestinal barrier disruption and inflammatory responses