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This is because SAMe can easily donate a methyl group, or accept one back, keeping the body's biochemistry flexible

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Quillen et al., 2020

PepH3-modified nanocarriers for delivery of therapeutics across the blood-brain barrier

Studies over the past decade have shown that although autophagy was initially thought to be a large-scale degradation pathway stimulated by cellular stressors, including starvation, autophagy can also selectively identify specific types of cargo for degradation [26, 27]