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Evidence should be that the oral iron therapy did not work, or was contraindicated or intolerable

And they work, for some people

Research-grade GHK-Cu is available from suppliers that publish complete certificates of analysis and operate under research-use-only labeling

While short-term results showed clinical improvement in patient MRI scores, improvement over conventional microfracture/OATS procedures has not been proven

there are little data on the safety of continued use of these agents in patients who develop an infection while on therapy, although anecdotal evidence suggests that they can safely be restarted in many cases after the infection has resolved