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This work was further supported by MHRUK and Angharad-Dodds Bursaries to M.B

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Epidemiologic evidence suggests that gut flora disruption due to antibiotic use early in life is associated with an increased risk of developing IBD (258), particularly in the first year of life, as antibiotic use may cause intense and prolonged microbial disruption at a critical time and have long-term effects on the immune system, increasing its risk of future IBD

Response: We appreciate and acknowledge commenters' concerns regarding the CPT coding

Med Sci Monit 11(6):288 Scholtens RM, van Munster BC, van Kempen MF, de Rooij SEJA (2016) Physiological melatonin levels in healthy older people: a systematic review