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doi: 10.21873/CGP.20021 72 ColellaBColardoMIannoneGContadiniCSaiz-LaderaCFuocoCet al

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The underlying mechanism through which the circadian rhythm regulates testosterone secretion may involve the activation of the PKAsteroid acute regulatory protein signaling pathway [71]

Oxidative stress response is clock dependent, as many of the antioxidant enzymes display circadian variations [48,49,50] and BMAL1 plays an important role in their regulation [51]