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While the first studies showing this were in mice [14], human studies have corroborated these findings [200], although its importance in relationship to traditional clearance pathways across the BBB and subarachnoidal granulations has been challenging to quantify

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In the context of this review, it is worth mentioning that copper is a transition metal that can exist in both oxidation and reduction states

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2-[[[(1,1-Dimethyl-2-hydroxyethyl)amino]carbonyl]amino]-N-(2,6-dimethylphenyl)-6-benzothiazolcarboxamid