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Transient striatal delivery of GDNF via encapsulated cells leads to sustained behavioral improvement in a bilateral model of Parkinson disease

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Drug treatment of PD motor symptoms is centred around pharmacological dopamine substitution with levodopa still being considered the most efficacious agent, while dopamine agonists (DA agonists) have overall smaller effect size and greater risk of troublesome adversity including daytime sleepiness and impulse dyscontrol [6,7,8,9]