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The BBB consists of endothelial cells tightly joined by tight junctions, supported by astrocytic end-feet and pericytes, which collectively regulate the movement of ions, nutrients, and metabolic waste across the barrier while preventing the entry of pathogens, toxins, and potentially harmful immune cells (Abbott et al., 2010)

Other Complications Associated with Vitamin B12 Deficiency in Patients with T2D on Metformin Therapy Besides neuropathy and anemia, a limited number of studies have explored the potential link between vitamin B12 deficiency and other complications in patients with T2D on metformin therapy

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In order to focus sharply, three physiological responses, known as the triad of accommodation, are produced by a change in pupil size, a change in shape and position of the lens, and ocular convergence

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