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The utility of this stimuli-responsive platform is demonstrated through two complementary in vivo applications: tumor-targeted prodrug activation triggered by the reductive tumor microenvironment in a 4T1 breast cancer model, and repeatable, on-demand local anesthesia controlled by 405 nm light

doi:10.1351/pac199466051077

Its deficiency can lead to neurotoxic effects, including oxidative stress, vascular damage, and neurodegeneration, contributing to cognitive decline and mental health issues

Subsequent cell- and animal- based assays confirmed that Al 2 O 3 NPs caused mitochondria-dependent apoptosis and oxidative stress either in vitro or in vivo, which were consistent with the trends of gene regulation