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Tong L, Wang L, Yao S, et al

The fight against obesity escalates: new drugs on the horizon and metabolic implications

Moreover, after caloric restriction, obese subjects showed weight loss together with ameliorated IR, reduced ER stress markers and improved mitochondrial function [53], suggesting the link between ER stress and abnormal lipid metabolism/IR

H tr lm se kht l chn lng v gim tnh trng mn trng c ca ch em

Therefore, mitochondrial dysfunction prevents cells from meeting their energy requirements and involves impairment of neuronal communication, cellular resilience, and hippocampal neurogenesis, which leads to mood and psychiatric disorders (Perkins et al., 1997