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Moreover, in contrast to asthma and COPD, where enhanced SubP and/or tachykinin signaling is potentially pathogenic, a decrease in SubP-mediated secretion in CF might be of detriment [99]

As stated in the proposed rule (89 FR 62104), we believe that few manufacturers will submit a rebate reduction request form due to the statutory specifications regarding eligible drugs, as well as the policy criteria finalized in this rule