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K.DebnathS.et al (2022)

In vitro studies using cultured ovarian cells have demonstrated a direct metformin effect on ovarian steroidogenesis (Kurzthaler et al., 2014)

Nevertheless, genetic evidence stemming from the use of engineered strains of mice has provided significant insight into the overlapping and complementary metabolic effects that physiological autophagy and the control of mTOR activity exert during fasting and nutrient overload