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(2015) reported that DHA prevents A aggregation in APP/PS1 transgenic rat model of AD, but also suggested to combine DHA with other medications because DHA still increases less toxic fibrillar A oligomers

Despite the short plasma half-life, downstream biological effects in tissue persist substantially longer, consistent with a signaling cascade rather than direct dose-response activity

This observation, combined with evidence that older adults have blunted MOTS-c responses to exercise, supports the hypothesis that declining mitochondrial peptide signaling contributes to the reduced exercise adaptability seen in aging

ZhangYXuDQiHYuanYLiuHYaoSet alEnriched environment promotes post-stroke neurogenesis through Nf-b-mediated secretion of Il-17a from astrocytes

To confirm that the cellular proliferation induced by the dimeric macrocycles involved the promotion of DNA synthesis in response to Met signalling, we monitored DNA synthesis in normal HPAEC (human pulmonary artery endothelial cells)