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NAD+ has been found to boost the production of a number of compounds that play a critical role in skin health such as: Collagen Keratin Elastin Hyaluronic acid Epidermal biopolymers (proteins) We produce NAD naturally however as we age, we decrease the production (very similar to how we lose collagen as we age) The reduction of NAD through aging leads to energy loss, mental fatigue, wrinkles, and frequent sickness

Unlike a stimulant such as caffeine, which spikes the central nervous system within twenty minutes, MOTS-c works at a deep, cellular level

doi: 10.1210/jcem.80.9.7673411 140 FrieboesRMAntonijevicIAHeldKMurckHPollmcherTUhrMet al

Key findings from receptor studies [2] : Long-term studies in -AR knockout mice showed no body weight reduction or lipolysis increases This verified the receptor pathways importance for sustained metabolic effects Acute experiments showed AOD9604 increased energy expenditure even in knockout mice Results suggest -AR expression enhances sensitivity but additional mechanisms exist beyond the direct receptor activation cAMP-PKA-HSL Pathway Activation The peptide triggers increases in intracellular cyclic AMP (cAMP) within adipocytes

The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD(+) decline