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Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift

Due to the already sensitive nature of dopaminergic neurons to redox imbalance and ROS generation, the additional reduction of an antioxidant like GSH causes neuron loss (Smeyne and Smeyne, 2013)

Direct stimulation of K(ATP) channels by exogenous and endogenous hydrogen sulfide in vascular smooth muscle cells

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They possess multiple cell-surface receptors which react to various stimuli and, after activation, release numerous mediators including histamine, heparin, cytokines, prostaglandins, leukotrienes and proteases (153)