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Glutamate regulates Treg cell subset differentiation and their suppressive function

Given this, and that BIN1 has been shown to be predominantly localised to white matter in the brain and expressed primarily in mature OLGs [86], it is reasonable to hypothesise that the involvement of BIN1 gene in disease processes may be mediated through DNA methylation changes affecting OLGs

Semin Cancer Biol 76:8698

At present, the FDA has approved a variety of monoclonal antibodies targeting angiogenesis signaling pathways (such as bevacizumab and cetuximab, etc.) and tyrosine kinase inhibitors (sorafenib and lenvatinib, etc.) for the treatment of tumors, and many preclinical studies have demonstrated their significant anti-tumorigenesis effects (223)