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Around 1520% of patients with IBD demonstrate hypermethylation when treated with thiopurines, resulting in preferential metabolism of MP to methylmercaptopurine (MeMP)[54]

We subsequently investigated the cytotoxic effects of HCFe nanozyme in combination with CDDP on CDDP-resistant ESCC cells

doi: 10.1038/s41564-023-01561-1 54 ChenY

In addition, PRR activation also increases the expression of MHC molecules, costimulatory molecules (CD40, CD80, CD86, et al.), and various cytokines (such as IL-12, IL-10, IL-23, TNF-), transforming quiescent immature DCs into fully functional mature DCs capable of activating and shaping T cells[13]