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[371] Given the limited applicability of the trials' exclusion criteria to many RP patients, it's unlikely that future trials will include such individuals

Glutathione synthetase deficiency, an inborn error of metabolism involving the gamma-glutamyl cycle in patients with 5-oxoprolinuria (pyroglutamic aciduria)

In summary, GW501516, a PPAR-beta/delta agonist, appears to mitigate kidney inflammation downstream of AT1r activation in a high-fructose diet-induced model