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Less commonly, more serious complications can arise, including: an abscess, or collection of pus tissue necrosis, or tissue death granuloma, or inflammation in the tissue muscle fibrosis, or scarring of muscle tissue hematoma, where blood seeps out of blood vessels into the surrounding tissue injury to blood vessels and nerves People who notice the following symptoms should call a doctor immediately: severe pain at the injection site prolonged or excessive bleeding tingling or numbness around the muscle redness, swelling, or warmth at the injection site drainage at the injection site signs of an allergic reaction, such as swelling or breathing problems Intramuscular injections are a common and effective way to deliver medication

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Furthermore, folates are substrates for less-selective transport proteins like organic anion transporter OATP1B1, multidrug resistance-associated proteins (MRPs), and the breast cancer resistance protein 275,886

Before each injection, remove the vial from the refrigerator and allow it to warm to room temperature for 15-20 minutes