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Sies H, Matsumoto H

Ethics approval and consent to participate This study was approved by the Institutional Research Ethics Committee of the First Affiliated Hospital with Nanjing Medical University (approval number: 081102), and the parents or legal guardians of all participants provided written informed consent

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Instead, various transcription factors more likely respond to certain threshold levels of ROS and RNS in a manner that is dependent on both concentration and duration and is likely influenced by the presence of inflammation, DNA damage, metabolic stress, and other factors