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In infected animals, ESC reduced inflammation, restored goblet cell and tight junction proteins, helped reestablish microbial balance, and decreased cecal tissue damage by activating Nrf2 signaling (Xu et al

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In contrast to peripheral sensitization where reduction in pain threshold and amplification in nociceptor responsiveness occurs in the peripheral axonal terminals (Hucho and Levine, 2007), central sensitization refers to heightened nociceptor responsiveness in the CNS and spinal dorsal horn to afferent inputs, leading to hypersensitivity to suprathreshold stimuli, increased responsiveness to innocuous stimuli, and enlarged receptive fields (Woolf and Salter, 2000)